DMAA is a synthetic drug found in dietary supplements and encouraged to boost weight loss and athletic performance. For many decades, it was utilized as a nasal decongestant but was removed from the marketplace because of many security concerns. What are the health consequences and dangers of DMAA? Read on to learn.
Disclaimer: By writing this post, we’re not advocating this medication. Some of our readers who were already taking the drug requested that we commission a post on it, and we are just providing information that is offered in the clinical and scientific literature.
As a matter of fact, we strongly advise against using unapproved materials, especially the ones with demonstrated serious health risks.
What Is DMAA?
1,3-Dimethylamylamine, also known as DMAA or geranium extract, is a stimulant commonly found in supplements. Though DMAA’s chemical structure is very similar to chemicals utilized in geraniums, the DMAA used in dietary supplements is artificial.
DMAA has supposedly been isolated from geranium plants however several reports failed to confirm that finding.
In 1944, Eli Lilly and Company introduced DMAA as a nasal decongestant. But, DMAA was removed from the market in 1983.
DMAA reappeared in 2006 under the title Geranamine as a crucial component in weight reduction and athletic performance dietary supplements.
Because of its reintroduction, DMAA has become the subject of serious debate because of alarming concerns about the safety of the product. In 2012, the Food and Drug Administration (FDA) required 10 makers of DMAA-containing goods to show the safety of DMAA in their own goods.
DMAA is notorious for increasing athletic performance and was banned by numerous sports authorities. In reality, DMAA behaves similar to cocaine and methamphetamine, includes a higher potential for abuse, and might lead to serious unwanted effects.
What Exactly Does DMAA Do?
Though the precise mechanism of action of DMAA is still unknown, this drug acts by imitating the impact of individual hormones such as adrenaline. DMAA functions on the brain’s reward system to boost vitality and on blood vessels to improve blood pressure.
By mimicking Adrenalin, it triggers the fight-or-flight response, very similar to other stimulants. This can produce a subjective”high” and contribute to misuse. It has been used to improve energy during workouts, for weight loss, as celebration pills, and even in the army, often marketed as a”legal high”.
Can Be DMAA illegal?
DMAA has been associated with dangerous, possibly deadly side effects. As a result of this, DMAA-containing products are illegal in several countries, such as the USA and Canada.
Outcomes of DMAA
The majority of the research about the effects of DMAA is based on dietary supplements containing DMAA. The decisions may be misleading since it is not sure the effects are caused by DMAA. Nearly all the studies looked at a specific supplement comprising DMAA, OxyELITE Pro, which is currently under legal evaluation.
1) Fat Burning
A dietary supplement comprising DMAA, OxyELITE Guru, contributed to body fat loss in 32 healthy adults (double-blind randomized controlled trial, 1 capsule/day for two weeks).
Additionally, it increased fat breakdown and increased body temperature in 12 healthy adults (double-blind randomized controlled trial), which can be considered to lead to body fat reduction in the long term.
2) Effects on Short-Term Memory and Reflexes
To examine if DMAA has the capability to be used in stroke recovery in sports, its cognitive effects were analyzed in one study (crossover) of 12 healthy young adults. The ingestion of 5.5 g of a nutritional supplement comprising DMAA (Jacked 3D) improved reflexes and short-term memory.
3) Physical Performance
In rats, high doses of a dietary supplement comprising DMAA (OxyELITE Guru ) improved exercise functionality. But after 4 months of daily intake, it lost its impact.
How Long Does DMAA Stay On Your System?
When taken orally, DMAA takes around 8 minutes to be absorbed into the bloodstream. Its half-life in the human body is 8.5 hours on average, and it takes more than 24 hours to eliminate it entirely from your system .
DMAA Negative Effects
DMAA is an unapproved material we strongly advise against. Be sure to consult with your health care provider if you’re considering it. If you have been subjected to DMAA and expertise poisoning, urgently contact a poison control center near you (call 1-800-222-1222).
DMAA commercialization was banned by the FDA because of its dangerous side effects.
Some research found DMAA usage, in a low dose (25 mg) and doses around 75 mg with 250 milligrams of caffeine to be secure. However, of the 8 studies that looked at DMAA, 6 were partially or completely funded by companies that make DMAA nutritional supplements.
The question of whether there is there a safe dose of DMAA still remains controversial.
In 2013, 36 individuals taking a nutritional supplement containing DMAA, OxyELITE Guru, were hospitalized for liver damage. Of the 36, one person died and 2 individuals required a liver transplant. All were taking the recommended dose (1-3 scoops or capsules/day). But, 27 of those people were swallowing a DMAA-free variant of OxyELITE Guru (Super Thermo capsules). It is difficult to ascertain which chemical was poisonous.
There have been at least 3 reports of people with brain bleeding after the usage of DMAA. The users reported swallowing DMAA often with alcohol or caffeine.
A 26-year-old healthier man suffered a severe aggravation and mind bleeding after consuming 3 scoops (recommended dose) of a dietary supplement comprising DMAA, Jack3d.
Increased Heart Rate and Blood Pressure
The ingestion of two capsules of a nutritional supplement containing DMAA (OxyELITE Pro) led to an increased heart rate and blood pressure in 12 healthy adults (double-blind randomized controlled trial).
56 cases of DMAA exposure in healthy adults were analyzed for unwanted effects, most (80%) from taking OxyELITE Pro before it was banned. Almost a third of the patients had a notable increase in heart rate but that effect might be attributed to other substances like caffeine.
A dose of 25 milligrams of DMAA didn’t have any impact on heart rate or blood pressure in 8 healthy adults.
A wholesome 22-year-old man suffered a heart attack following consuming a dietary supplement comprising DMAA (Jack3d) and caffeine for 3 months.
Nausea and Vomiting
In 1 review, 15 percent of the 56 patients experienced nausea and vomiting after consuming DMAA supplements. Most were carrying OxyElite Pro, so other substances from the item could have led to the side effects .
At a mobile study, DMAA blocked the activity of two major enzymes (cytochrome P450 2D6 and 3A4), which break down roughly 25 percent of commonly used drugs. They help to break down and eliminate antidepressants, antipsychotics, opioids, and drugs for heart problems. Once blocked, medication can build up in the body and reach dangerously high levels, potentially causing liver damage.
The combination of alcohol and DMAA in OxyELITE Pro raises the risk of liver damage.
A 21-year-old guy experienced brain bleeding after consuming alcohol, caffeine, and 556 mg of DMAA.
DMAA and caffeine are generally found together in dietary supplements. 50 healthy men consumed DMAA and caffeine in various concentrations and there was no change in blood pressure and heart rate, even in a high dose (250 mg of caffeine + 50 mg of DMAA, RCT).
The combination of both DMAA and caffeine did not raise the heart rate of 10 healthy men even at a high dose of caffeine (250 mg of caffeine + 75 milligrams of DMAA, DB-RCT).
However, as mentioned, one person experienced brain degeneration after combining caffeine, alcohol, and 556 mg of DMAA.
Bottom Line: Is DMAA Safe?
According to the FDA and the aforementioned reports, DMAA is not secure as at least 4 human deaths have been linked to its use, including two energetic U.S. soldiers along with a runner during a marathon. In one of the cases, the consumer consumed DMAA, alcohol, alcohol, and caffeine at the same time.
DMAA Drug Test
DMAA concentration from the body may be quantified in urine and blood to check for DMAA intoxication.
In most sports, if DMAA is detected, the athlete could most probably be disqualified as DMAA is a banned substance.
DMAA Supplements and Products
DMAA is frequently abused as”party pills”, together with other drugs and alcohol.
- “Raw” DMAA powder
- Supplements comprising DMAA, the most typical being OxyELITE Pro and Jack3d
Geranium Oil Extract?
The presence of DMAA in geranium oil extract is contentious. There are studies that confirm a small number of pure DMAA in geranium plants, but other research denies it.
Despite the lack of proof, many products market DMAA as natural.
The most common form of DMAA is pre-workout supplements. These nutritional supplements often contain caffeine, which interacts with DMAA to improve athletic performance.
Many dietary supplements used to contain DMAA because of its weight-loss properties. However, it had been prohibited from the FDA.
The most popular supplements containing DMAA are OxyELITE Guru and Jack3d. There are more than 250 dietary supplements containing DMAA on the black market, including:
- Biorhythm SSIN Juice
- Code Red
- Hemo Rage Black
- Lean Efx
- Lipo-6 Black Ultra
- Lipo-6 Black
- Lipo-6 Black Hers Ultra
- Lipo-6 Black Hers
- MethylHex 4,2
- Nitric Blast
- OxyELITE Pro
The ingredients listed for OxyELITE Pro are 119.5 milligrams of a proprietary mix (Bauhinia purpurea L. (Leaf and Pod) infusion, Bacopa monnieri (Leaf) Extract, 1,3-Dimethylamylamine HCl (DMAA), Cirsium oligophyllum (Plant) Extract, Pausinystalia Yohimbe (Bark) Extract) and 100 milligrams of caffeine.
The ingredients listed for Jack3d is 4,145 milligrams of a proprietary mix of arginine a-ketoglutarate, creatine monohydrate, b-alanine, caffeine, 1,3-dimethylamylamine (DMAA), and schizandrol.
DMAA Dangers Compared To Other Questionable Compounds
Adderall is a drug used in the treatment of ADHD and mistreated to enhance athletic performance. Unlike DMAA, Adderall is legal but prohibited from professional sports.
Considering Adderall is an addictive stimulant, its abuse may also result in serious health problems.
Adderall consumption has been linked to heart attacks and even sudden death. One 20-year-old man had a heart attack following consuming 30 mg of Adderall. But, as with DMAA, alcohol abuse might have been a contributing factor.
But when used as prescribed, Adderall has significantly less pronounced side effects. The most common reported adverse effects of Adderall are increased heart rate and blood pressure with little long-term damage.
Ephedrine is a medication used to improve blood pressure during anesthesia, as a decongestant, and for weight loss. Ephedrine is a stimulant and may lead to abuse and dependence.
The use of ephedrine from the United States and Canada is not illegal but limited to a specific dosage. Based on Health Canada, the ingestion of ephedrine must not exceed 32 mg/day for any more than seven days.
The consumption of ephedrine has been associated with various side effects. At a meta-analysis, ephedrine was linked to mental health, gut, and heart conditions.
Dimethylhexylamine (DMHA), also known as Octodrine, is a stimulant with similar chemical properties and structure as DMAA. It had been previously used as a nasal decongestant in the 1950s and reintroduced in the marketplace as a nutritional supplement just as DMAA had been .
DMHA also purportedly promotes energy levels, concentrate, concentration, and can be mainly used for weight loss.
DMHA isn’t prohibited in the United States as it has not revealed any serious side effects. However, some adverse effects are high blood pressure, shortness of breath, and higher body temperature. DMHA is banned by sports authorities as it might improve athletic performance.
Dosage, Limitations, and Reviews
There is no safe dose for DMAA, as it’s an unapproved new drug that poses a significant safety threat. Below is a summary of the dosages used in scientific study, outlined for informational purposes. We highly advise against the use of DMAA.
The content of DMAA in dietary supplements containing DMAA varies a lot, as it could range from 25 to 278 mg each capsule, depending on the item. A dose of up to 75 milligrams DMAA and 250 mg caffeine was deemed”safe” as it did not increase heart rate in a few trials.
Limitations and Caveats
- Contradicting research: There are several studies that reach opposing conclusions regarding DMAA’s safety and origin (natural or artificial).
- Insufficient research examining the effects of DMAA in isolation: the majority of the research about the consequences of DMAA is based on dietary supplements containing DMAA. The dosage of DMAA from the supplements isn’t specified and is usually listed as a proprietary combination. The decisions could be misleading since it is not certain the effects are caused by DMAA.
- Biased research: Several research that supported DMAA’s security were supervised by a company responsible for producing dietary supplements containing DMAA.
The opinions expressed in this section are only from the users who may or may not have a medical background. We do not endorse any specific solution, service, or therapy. Don’t consider user adventures as medical information. Never delay or disregard seeking professional medical advice because of something you’ve read on our website.
Most users stated that they were astounded by the weight loss properties of a DMAA-containing product (OxyELITE Guru ). Additionally, many of these were impressed by the amount of energy that they felt after swallowing it.
Users also admired the short amount of time it takes to notice DMAA’s effects.
The major criticism that consumers had of DMAA was the presence of intense headaches after consuming the item for the very first time. Additionally, some folks suffered from headaches after they stopped taking DMAA.
Additionally, many people experienced nausea sometimes after swallowing DMAA.